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Myasthenia Gravis and Ischemic Stroke: A Bidirectional Mendelian Randomization Study
Chen Liu1,2,3,4, Chengyuan Mao1,3,4, Shen Li1,2,3,4
1Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Current Neurovascular Research
|July 5, 2023
Summary
This study investigated if myasthenia gravis (MG) causes ischemic stroke (IS). Mendelian randomization analysis found no evidence of a causal link between MG and IS, or vice versa.
Area of Science:
- Neurology
- Immunology
- Cardiovascular Science
Background:
- Autoimmune diseases are linked to cardiovascular and cerebrovascular conditions.
- The potential causal relationship between myasthenia gravis (MG) and ischemic stroke (IS) remains uncertain.
Conclusions:
- Bidirectional Mendelian randomization analysis did not support a causal relationship between genetically predicted myasthenia gravis and ischemic stroke.
- Findings contrast with some observational studies, highlighting the importance of genetic evidence in establishing causality.
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