Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

4.3K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

9.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.0K
Computed Tomography01:10

Computed Tomography

4.6K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.6K
Radiation: Applications01:17

Radiation: Applications

1.2K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
1.2K
Cancer Survival Analysis01:21

Cancer Survival Analysis

397
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
397

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pancreatic Cancer Detection Consortium Biomarker Bakeoff: A Phase II Blinded Biomarker Validation and Panel Discovery Study.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Natural history of HPV-16 E6 serology among cancer-free men in a multicenter longitudinal cohort study.

Journal of the National Cancer Institute·2024
Same author

Designing Rigorous and Efficient Clinical Utility Studies for Early Detection Biomarkers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2024
Same author

NCI Resources for Cancer Immunoprevention Research.

Cancer immunology research·2024
Same author

Revisiting the standard blueprint for biomarker development to address emerging cancer early detection technologies.

Journal of the National Cancer Institute·2023
Same author

Challenges to Using Big Data in Cancer.

Cancer research·2023

Related Experiment Video

Updated: Jul 24, 2025

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography
10:10

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography

Published on: July 29, 2011

15.3K

PreCancer Atlas: Present and Future.

Sudhir Srivastava1, Paul D Wagner1, Shannon K Hughes2

  • 1Division of Cancer Prevention, National Cancer Institute, NIH, Rockville, Maryland.

Cancer Prevention Research (Philadelphia, Pa.)
|July 5, 2023
PubMed
Summary

Precancer atlases map the evolution of lesions, aiding cancer research. The Human Tumor Atlas Network (HTAN) builds 3D cancer atlases to understand progression, regression, or equilibrium.

More Related Videos

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

13.8K
Author Spotlight: Segmentation and VR for Advanced Neurovascular Interventions
06:18

Author Spotlight: Segmentation and VR for Advanced Neurovascular Interventions

Published on: April 5, 2024

1.1K

Related Experiment Videos

Last Updated: Jul 24, 2025

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography
10:10

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography

Published on: July 29, 2011

15.3K
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

13.8K
Author Spotlight: Segmentation and VR for Advanced Neurovascular Interventions
06:18

Author Spotlight: Segmentation and VR for Advanced Neurovascular Interventions

Published on: April 5, 2024

1.1K

Area of Science:

  • Oncology
  • Genomics
  • Pathophysiology

Background:

  • Precancer atlases offer novel insights into the topographic and morphologic structures of precancerous lesions.
  • Understanding the relationship between precancerous states and cellular, molecular, genetic, and pathophysiologic factors is crucial for early cancer detection and intervention.

Approach:

  • This review highlights the Human Tumor Atlas Network (HTAN) as a model for constructing 3D cellular and molecular atlases of human cancers.
  • It details the collaborative efforts within HTAN to study the progression of premalignant lesions to invasive cancer, or their regression and equilibrium.
  • The approach focuses on illustrating the construction process and the research methodologies employed by HTAN.

Key Points:

  • HTAN is constructing comprehensive 3D atlases of human cancers, from precancerous lesions to advanced disease.
  • Research within HTAN investigates the dynamic behavior of premalignant lesions: progression, regression, or stable equilibrium.
  • The network emphasizes a collaborative approach to integrate diverse data types for a holistic understanding of cancer evolution.

Conclusions:

  • The development of precancer atlases, exemplified by HTAN, has the potential to transform the understanding of cancer development.
  • Lessons learned from HTAN's experience can guide future efforts in building precancer atlases, focusing on logistics, rationale, and implementation.
  • Continued research and collaboration are essential for advancing the field of precancer atlases and their clinical applications.