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Elastomeric PGS Scaffolds in Arterial Tissue Engineering
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Elastomeric PGS Scaffolds in Arterial Tissue Engineering

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Scaffolds for Use in Blood Vessel Bioengineering: What are the Prospects?

Leonardo Rufino Garcia1, André Monti Garzesi1, Flávio de Souza Brito2

  • 1Hospital das Clínicas de Botucatu e Faculdade de Medicina de Botucatu - Universidade Estadual Paulista (UNESP) - Serviço de Cirurgia Cardiovascular e Transplante Cardíaco, São Paulo, SP - Brasil.

Arquivos Brasileiros De Cardiologia
|July 5, 2023
PubMed
Abstract

No abstract available in PubMed .

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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