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Related Experiment Video

Updated: Jul 24, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Thermal- and pH-responsive triple-shape memory hydrogel based on a single reversible switch.

Yufang Song¹, Hui Lv², Xiaorong Wang²

¹Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. p.ma@jiangnan.edu.cn.

|July 5, 2023

Summary

This summary is machine-generated.

Researchers developed a novel triple-shape memory hydrogel that responds to pH and temperature. This material uses a unique ureido-pyrimidinone system to enable multiple shape changes from a single transition phase.

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Area of Science:

Materials Science
Polymer Chemistry
Smart Materials

Background:

Shape memory hydrogels are advanced materials with the ability to recover programmed shapes in response to stimuli.
Existing shape memory hydrogels often require multiple transition phases or complex chemistries to achieve multi-shape memory effects.

Purpose of the Study:

To develop a novel triple-shape memory hydrogel with multiple shape programming capabilities.
To utilize a single reversible switch phase for pH and thermal responsiveness.
To investigate the role of a ureido-pyrimidinone (UPy) system in controlling shape memory behavior.

Main Methods:

Fabrication of a hydrogel network incorporating a high-density quadruple hydrogen-bonding ureido-pyrimidinone (UPy) system.
Investigating the dissociation and reassociation behavior of the UPy system under varying pH and temperature conditions.
Characterizing the hydrogel's ability to freeze and unfreeze temporary shapes based on stimuli-induced phase transitions.

Main Results:

Successful fabrication of a pH- and thermal-responsive triple-shape memory hydrogel.
Demonstrated that varied degrees of UPy dissociation and reassociation act as distinct memory elements.
Achieved multiple temporary shape programming using a single transition phase due to a large dissociative differential.

Conclusions:

The novel UPy-based hydrogel offers a versatile platform for triple-shape memory applications.
The single transition phase design simplifies the material's response mechanism while enabling complex shape programming.
This approach provides multiple programming windows for temporary shapes, expanding the utility of shape memory hydrogels.