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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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The Relationship Between Kiritsu-Meijin-Derived Autonomic Function Parameters and Visual-Field Defects in Eyes with
Yurina Yamada1, Naoki Kiyota1, Mitsuhide Yoshida1
1Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Current Eye Research
|July 5, 2023
Summary
Lower autonomic activity and recovery in open-angle glaucoma patients correlate with worse visual field defects. Kiritsu-Meijin device measurements may aid glaucoma management.
Area of Science:
- Ophthalmology
- Autonomic Neuroscience
- Medical Technology
Background:
- Open-angle glaucoma is a leading cause of irreversible blindness.
- Autonomic dysfunction has been implicated in glaucoma pathogenesis.
- Non-invasive methods to assess autonomic function could aid in glaucoma management.
Purpose of the Study:
- To investigate the association between autonomic parameters measured by the Kiritsu-Meijin device and visual-field defects in open-angle glaucoma patients.
- To explore potential clinical utility of autonomic parameter assessment in glaucoma.
Main Methods:
- A cross-sectional study of 42 open-angle glaucoma patients (79 eyes).
- Autonomic parameters (activity, balance, reaction, switchover, recovery) were measured using the Kiritsu-Meijin device during sitting and standing phases.
- Correlations between autonomic parameters and Humphrey visual field mean deviation and total deviation were analyzed using linear mixed-effects models.
Main Results:
- Significant positive correlations were found between activity, balance, and recovery with mean deviation values.
- Activity was more strongly associated with inferior total deviation than superior total deviation.
- Recovery showed a stronger association with central to inferior total deviation compared to superior total deviation.
Conclusions:
- Lower autonomic activity and recovery are linked to more severe central and/or inferior visual field defects in open-angle glaucoma.
- Kiritsu-Meijin device-based autonomic function measurements show potential clinical relevance for glaucoma management.
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