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Updated: Jul 24, 2025
A Standardized Approach for Multispecies Purification of Mammalian Male Germ Cells by Mechanical Tissue Dissociation and Flow Cytometry
Published on: July 12, 2017
[Diagnosis of germ cell tumors]
1Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Kirrberger Str., Gebäude 90, 66421, Homburg/Saar, Deutschland. armin.bachhuber@uks.eu.
Clinical/Methodical Issue:
Intracranial germ cell tumors are rare central nervous system (CNS) diseases in Europa and America. Because of their low frequency and lack of typical imaging features, they represent a difficult diagnosis for any radiologist.
Standard Radiological Methods:
Magnetic resonance imaging (MRI) is a sensible diagnostic tool for the initial diagnosis of germ cell tumors, although it has limitations.
Methodological Innovations:
So far, no typical morphologic pattern as a red flag for germ cell tumors has been identified. Correlation with clinical symptoms and laboratory results is mandatory.
Performance:
In certain cases, combining the location of the tumor and clinical findings may allow a diagnosis to be made even without histologic confirmation.
Practical Recommendations:
In addition to imaging, the radiologist needs the age, background, and laboratory findings to be able to make an accurate diagnosis.
