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Updated: Jul 24, 2025

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
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Role of homeobox d10 gene targeted signaling pathways in cancers

Hemapreethi Surendran1, Thirunavukkarasu Palaniyandi2, Sudhakar Natarajan3

  • 1Department of Biotechnology, Dr. M.G.R Educational and Research Institute, Deemed to be University, Chennai 600095 Tamil Nadu, India.

Pathology, Research and Practice
|July 5, 2023
PubMed

Insights

Homeobox D10 (HOXD10) gene dysregulation contributes to cancer metastasis. Understanding HOXD10

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Homeobox D10 (HOXD10) is a crucial transcription factor for development.
  • Dysregulation of HOXD10 impacts cell differentiation and homeostasis, potentially leading to tumors.
  • HOXD10 is upregulated in various cancers, including breast, gastric, and prostate cancer.

Purpose of the Study:

  • To review the role of HOXD10 dysregulation in cancer metastatic development.
  • To explore HOXD10-associated signaling pathways and their impact on cancer.
  • To discuss HOXD10's role in therapeutic resistance and its potential as a cancer treatment target.

Main Methods:

  • This is a narrative review.
  • Literature search on HOXD10, gene expression, signaling pathways, and cancer metastasis.
  • Analysis of existing studies linking HOXD10 to various cancer types and therapeutic resistance.

Main Results:

  • HOXD10 gene expression is altered in multiple cancers, influencing tumor signaling pathways.
  • Dysregulation of HOXD10 contributes to the metastatic progression of cancer.
  • HOXD10 may play a role in mediating resistance to cancer therapies.

Conclusions:

  • HOXD10 dysregulation is implicated in cancer metastasis and therapeutic resistance.
  • HOXD10 presents potential as a novel therapeutic target and biomarker in oncology.
  • Further research into HOXD10 pathways could lead to new cancer treatment strategies.
Keywords:
CancerGeneHOXD10Homeobox geneSignaling Pathway

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