Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

473
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
473
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

203
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
203
Management of Insomnia01:19

Management of Insomnia

281
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
281
Sedatives and Hypnotics Drugs: Benzodiazepines01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

300
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
300
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

198
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
198
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

324
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
324

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial intelligence-driven drug discovery: a new era in therapeutic innovation.

Bioorganic & medicinal chemistry·2026
Same author

Fermented Durian Tempoyak as a Source of Probiotics for Colorectal Cancer Prevention through Gut Microbiome Modulation.

Current gastroenterology reports·2026
Same author

A Review of Probiotic Interventions for Necrotizing Enterocolitis and Sepsis in Preterm Infants.

International journal of molecular sciences·2026
Same author

Serotonergic psychedelics for Autism spectrum disorder: Neurobiological mechanisms and translational prospects.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Stingless bee honey alleviates cognitive deficits and hippocampal neurodegeneration in an Alzheimer's model: Behavioural, neurochemical, and histological analyses.

AIMS neuroscience·2026
Same author

Establishment of a Sensitized 3D Spheroid Cancer Cell Model for Enhanced Anti-Cancer Drug Discovery.

Methods and protocols·2026

Related Experiment Video

Updated: Jul 24, 2025

Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

23.9K

Cannabinoids: Emerging sleep modulator.

Zhen Xuen Brandon Low1, Xin Ru Lee1, Tomoko Soga2

  • 1Neurological Disorder and Aging Research Group (NDA), Neuroscience Research Strength (NRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, 47500 Selangor, Malaysia.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|July 5, 2023
PubMed
Summary
This summary is machine-generated.

Cannabinoids modulate sleep by acting on cannabinoid receptors (CB1 and CB2). Targeting CB2 receptors may offer therapeutic benefits for sleep disorders without the adverse effects of CB1 receptor alteration.

Keywords:
CB1CB2Circadian rhythmEndocannabinoid systemSleepSleep disorder

More Related Videos

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.4K
Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
05:25

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

2.6K

Related Experiment Videos

Last Updated: Jul 24, 2025

Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

23.9K
Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.4K
Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
05:25

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

2.6K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Sleep Science

Background:

  • Sleep is vital for homeostasis, cognition, and overall health.
  • Dysfunctional sleep is linked to numerous health issues, including neurological disorders.
  • Cannabinoids, particularly via cannabinoid receptors (CB1 and CB2), influence sleep regulation.

Purpose of the Study:

  • To review the effects of the endocannabinoid system on the sleep-wake cycle.
  • To explore the neurobiological mechanisms of cannabinoid receptors in sleep physiology.
  • To assess the therapeutic potential of targeting cannabinoid receptors for sleep disorders.

Main Methods:

  • Review of recent findings on cannabinoid system alterations and sleep.
  • Exploration of cannabinoid receptor mechanisms influencing sleep and wakefulness.

Main Results:

  • Cannabinoid receptor modulation generally promotes sleep, reducing sleep latency and increasing non-rapid-eye movement sleep.
  • CB1 receptor alteration is associated with psychotropic side effects.
  • CB2 receptor alteration does not produce these adverse effects, suggesting therapeutic potential.

Conclusions:

  • The endocannabinoid system plays a significant role in regulating sleep.
  • Selective targeting of CB2 receptors presents a promising avenue for treating sleep disorders.
  • Further understanding of cannabinoid mechanisms is crucial for developing novel sleep therapies.