Related Experiment Video

Updated: Jul 24, 2025

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

9.7K

Beyond the Skin: Reduced Lung Function Associated With Atopic Dermatitis in Infants

Zeynep Gulec Koksal1, Pinar Uysal1

  • 1Department of Pediatric Allergy and Immunology, Aydin Adnan Menderes University Faculty of Medicine, Aydin, Turkey.

The Journal of Allergy and Clinical Immunology. in Practice
|July 5, 2023
PubMed

Insights

Tidal breath analysis (TBA) reveals reduced lung function in infants with atopic dermatitis (AD), indicating early airway obstruction. This method shows promise for objective clinical assessment in children with AD.

Area of Science:

  • Pediatric Pulmonology
  • Dermatology
  • Allergy Immunology

Background:

  • Atopic dermatitis (AD) is linked to a higher risk of developing asthma.
  • Lung function assessment in infants with AD is underexplored.
  • Tidal breath analysis (TBA) offers a potential method for evaluating lung function in this population.

Purpose of the Study:

  • To measure lung function using TBA in infants with AD and healthy controls (HCs).
  • To investigate the impact of AD severity, food sensitivity, and recurrent wheezing on TBA parameters.
  • To assess TBA's utility in detecting airway obstruction in infants with AD.

Main Methods:

  • A prospective cross-sectional study involving 230 infants (150 with AD, 80 HCs).
  • Lung function assessed via TBA.
  • Disease severity evaluated using SCORing Atopic Dermatitis; food sensitivity determined by IgE or skin prick tests.

Main Results:

  • Infants with AD exhibited significantly lower TBA parameters compared to HCs (P < .05).
  • Key parameters like expiratory flow and respiratory rate were reduced in the AD group.
  • The ratio of time to peak expiratory flow to expiratory time effectively differentiated AD with high sensitivity and specificity (AUC=0.826).

Conclusions:

  • TBA is a valuable tool for identifying expiratory airway obstruction in infants with AD.
  • Objective lung function data can be obtained using TBA for clinical use.
  • Bronchial obstruction in infants with AD is present regardless of disease severity or associated factors.
Abstract

Keywords:
Atopic dermatitisInfantLung functionTidal breath analysis

More Related Videos

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.2K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.4K

Related Concept Videos

Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
59.7K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.9K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
369