Related Experiment Video
Updated: Jul 24, 2025
11:49
Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
Published on: March 8, 2019
12.7K
Stainability of Acrylic Intraocular Lens With Brilliant Blue G: An In Vitro Study
1From the Departments of Ophthalmology, Muroran City General Hospital, Muroran City, Hokkaido, Japan (K.I.).
American Journal of Ophthalmology
|July 5, 2023
Summary
Acrylic intraocular lenses (IOLs) can be stained by Brilliant Blue G (BBG). Hydrophilic IOLs are more susceptible to BBG staining, necessitating careful washout during surgery.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Medical Device Engineering
Background:
- Brilliant Blue G (BBG) is used in ophthalmic surgery.
- Acrylic intraocular lenses (IOLs) are common implants.
- Understanding IOL-dye interactions is crucial for surgical safety.
Purpose of the Study:
- To evaluate the in vitro stainability of various acrylic intraocular lenses (IOLs) with Brilliant Blue G (BBG).
- To assess the impact of BBG staining on IOL optical properties.
Main Methods:
- Immersion of hydrophilic and hydrophobic acrylic IOLs in BBG solutions of varying concentrations and durations.
- Evaluation of BBG uptake, sustained release, and cross-sectional changes.
- Spectrophotometric analysis of optical property alterations in stained IOLs.
Main Results:
- All tested acrylic IOLs stained with BBG in a concentration- and time-dependent manner.
- Higher water content IOLs, particularly hydrophilic ones like LS313MF15, showed more pronounced staining.
- Blue-stained IOLs exhibited decreased light transmittance, especially between 610-620 nm.
Conclusions:
- Acrylic IOLs, especially hydrophilic types, are susceptible to BBG staining.
- Careful intraoperative washout of BBG is essential to prevent complications.
- Further research may be needed to develop BBG-resistant IOLs.
