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Transcription factor abnormalities in B-ALL leukemogenesis and treatment
Hongxin Yin1, Junfei Wang1, Yangxia Tan1
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Rui-Jin Hospital, School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200025, China.
Trends in Cancer
|July 5, 2023
Summary
Transcription factor rearrangements drive B cell acute lymphoblastic leukemia (B-ALL) by disrupting cell homeostasis. This review details six major TF abnormalities, their mechanisms, and therapeutic implications for B-ALL treatment.
Area of Science:
- Oncology
- Molecular Biology
- Hematology
Background:
- Transcription factors (TFs) and repressor proteins are crucial for cell homeostasis.
- TF abnormalities are frequent drivers of carcinogenesis in B cell acute lymphoblastic leukemia (B-ALL).
Purpose of the Study:
- To review the molecular mechanisms of six major TF rearrangements in B-ALL.
- To discuss therapeutic options and prognoses for patients with these TF abnormalities.
- To provide an overview of TF-driven carcinogenesis and therapeutic targets in B-ALL.
Main Methods:
- Literature review of molecular mechanisms.
- Analysis of TF rearrangements in B-ALL.
- Discussion of therapeutic strategies and patient outcomes.
Main Results:
- Detailed review of DUX4-rearranged (DUX4-R), MEF2D-R, ZNF384-R, ETV6-RUNX1, TCF3-PBX1, and KMT2A-R in B-ALL.
- Identification of TF abnormalities as key drivers of B-ALL.
- Exploration of treatment implications for specific TF rearrangements.
Conclusions:
- TF-based oncogenic fusions significantly contribute to B-ALL development.
- Understanding these mechanisms is vital for targeted B-ALL therapies.
- Further research into TF abnormalities can guide novel therapeutic strategies.
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