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CTCF and Its Multi-Partner Network for Chromatin Regulation.

Aylin Del Moral-Morales1,2, Marisol Salgado-Albarrán1,2, Yesennia Sánchez-Pérez3

  • 1Departamento de Ciencias Naturales, Universidad Autónoma Metropolitana-Cuajimalpa (UAM-C), Mexico City 05348, Mexico.

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|July 6, 2023
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Summary

CCCTC-binding factor (CTCF) is a key protein in genome organization. This review explores how CTCF partners with other molecules to regulate chromatin structure and gene expression, revealing its master regulatory role.

Keywords:
BORISCTCFCTCF-sKDMTETchromatin regulationdemethylasesepigeneticshistonelncRNAs

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Area of Science:

  • Epigenetics
  • Molecular Biology
  • Genomics

Background:

  • Architectural proteins are crucial for epigenetic regulation and gene expression control.
  • CCCTC-binding factor (CTCF) is a vital architectural protein maintaining chromatin's 3D structure.
  • CTCF's versatile genome organization mechanisms are not fully understood.

Purpose of the Study:

  • To review the interactions of CTCF with epigenetic regulators.
  • To elucidate CTCF's role in chromatin folding and gene expression.
  • To highlight the importance of CTCF partners in understanding chromatin regulation.

Main Methods:

  • Literature review of CTCF interactions.
  • Analysis of CTCF's role in epigenetic processes.
  • Exploration of CTCF's partnership with histone and DNA demethylases and lncRNAs.

Main Results:

  • CTCF interacts with histone and DNA demethylases.
  • CTCF is recruited by specific long non-coding RNAs (lncRNAs).
  • These interactions form a complex network regulating chromatin folding.

Conclusions:

  • CTCF partners are essential for its function as a master chromatin regulator.
  • Understanding these interactions provides insight into finely-tuned gene expression.
  • Further exploration of CTCF mechanisms is warranted.