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Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns
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Pathway and directional specificity of Hebbian plasticity in the cortical visual motion processing network
Michele Bevilacqua1,2, Krystel R Huxlin3, Friedhelm C Hummel1,2,4
1Defitech Chair in Clinical Neuroengineering, Neuro-X Institute (NRX) and Brain Mind Institute, EPFL, Geneva, Switzerland.
Iscience
|July 6, 2023
Summary
Cortico-cortical paired associative stimulation (ccPAS) selectively impacts brain pathways for motion discrimination. Backward ccPAS modulated alpha signals, predicting visual improvements and suggesting re-entrant MT-to-V1 pathway involvement.
Area of Science:
- Neuroscience
- Cognitive Science
- Neuroimaging
Background:
- Cortico-cortical paired associative stimulation (ccPAS) uses transcranial magnetic stimulation (TMS) to modulate synaptic plasticity.
- Understanding the specificity of ccPAS is crucial for its therapeutic applications.
Purpose of the Study:
- To investigate the spatial selectivity and oscillatory signatures of ccPAS along the motion discrimination pathway.
- To determine the causal role of specific pathways in motion perception and visual recovery.
Main Methods:
- Applied ccPAS along ascending (Forward) and descending (Backward) motion discrimination pathways.
- Analyzed changes in connectivity, oscillatory activity (gamma and alpha bands), and perceptual performance.
- Correlated neural modulation with visual improvements in healthy participants.
Main Results:
- ccPAS induced unspecific increases in bottom-up gamma band connectivity, likely due to task exposure.
- Backward ccPAS specifically modulated re-entrant alpha signals, distinguishing information transfer direction.
- Modulation of alpha signals predicted enhanced visual performance in participants.
Conclusions:
- Re-entrant alpha signals and MT-to-V1 low-frequency inputs causally contribute to motion discrimination and integration.
- ccPAS targeting re-entrant pathways offers potential for predicting and facilitating visual recovery.
- Residual re-entrant inputs to spared V1 neurons may play a role in visual recovery.
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