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Learning from cancer to address COVID-19
1Department of Molecular Genetics, National Institute of Oncology, Ráth György u. 7-9, Budapest, 1122, Hungary. olah.edit@oncol.hu.
Biologia Futura
|July 6, 2023
Summary
Cancer patients face severe risks from COVID-19. This review explores the cellular and molecular links between cancer and coronavirus disease 2019 (COVID-19), informing risk assessment and treatment strategies.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Cancer patients experienced disproportionately severe outcomes during the COVID-19 pandemic.
- Decades of cancer research provided crucial insights for addressing pandemic challenges.
Purpose of the Study:
- To summarize the biology and risk factors of COVID-19 and cancer.
- To present evidence on the cellular and molecular relationship between cancer and SARS-CoV-2.
- To explain the heightened risk of severe COVID-19 in cancer patients.
Main Methods:
- Literature review focusing on research from 2020-2022.
- Analysis of cellular and molecular mechanisms linking cancer and COVID-19.
- Examination of the hallmarks of cancer in the context of SARS-CoV-2 infection.
Main Results:
- Identified key cellular and molecular interactions between cancer and COVID-19.
- Provided insights into why cancer patients are at higher risk for severe COVID-19.
- Highlighted the role of mRNA technology in vaccine development.
Conclusions:
- Understanding the cancer-COVID-19 relationship aids in patient treatment and risk stratification.
- Advances in mRNA technology, including nucleoside modifications, revolutionized vaccine development for SARS-CoV-2.
- mRNA vaccines have saved millions of lives and opened new therapeutic avenues.
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