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Updated: Jul 24, 2025

Correlative Optical Spectroscopy and Mass Spectrometry Imaging Methodology to Visualise Drug Distribution in a Soft Tissue Section
Published on: June 20, 2025
Perspective: Mass Spectrometry Imaging - The Next 5 Years
Malcolm R Clench1, Laura M Cole2
1Centre for Mass Spectrometry Imaging, Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK. m.r.clench@shu.ac.uk.
Abstract:
In order to achieve even more widespread adoption over the next 5 years, a number of issues in mass spectrometry imaging need to be addressed. These are non-observation of compounds (due to ionization suppression), sample throughput, imaging of low-abundant species, and how to extract information from the large volumes of data generated. In this article, how current research indicates that these issues will be resolved along with potential application areas that MSI could look to exploit is discussed.
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