Related Experiment Video
Updated: Jul 24, 2025
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
1.7K
Recent advances in anaplastic thyroid cancer management
Sarah Hamidi1, Anastasios Maniakas2
1Department of Endocrine Neoplasia and Hormonal Disorders.
Summary
Recent advancements in anaplastic thyroid cancer (ATC) include new classifications and targeted therapies for BRAFV600E mutations. While promising, challenges like resistance and treatments for non-mutated cases remain.
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- Anaplastic thyroid cancer (ATC) is a rare and aggressive form of thyroid cancer.
- Recent WHO classification updates include squamous cell carcinoma as a subtype of ATC.
- Molecular profiling through next-generation sequencing (NGS) enhances understanding and prognostication of ATC.
Approach:
- Review of recent literature on ATC diagnosis and management.
- Analysis of the impact of BRAFV600E mutations and targeted therapies.
- Evaluation of emerging treatment strategies, including immunotherapy.
Key Points:
- BRAF-targeted therapies have revolutionized treatment for advanced/metastatic BRAFV600E-mutated ATC, improving outcomes and enabling neoadjuvant approaches.
- Development of resistance mechanisms to BRAF-targeted therapies is a significant clinical challenge.
- Combination of immunotherapy with BRAF/MEK inhibition shows promising survival benefits.
Conclusions:
- Significant progress has been made in characterizing and managing ATC, particularly for BRAFV600E-mutated cases.
- Curative treatment for ATC remains elusive, with limited options upon resistance to current therapies.
- Further research is needed to develop effective treatments for patients with non-BRAF-mutated ATC.
Related Concept Videos
01:27Tumor Immunotherapy
573
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
573
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K