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Cytokines and their role in cardiovascular diseases

Habib Haybar1, Bita Bandar2, Ekhlas Torfi3

  • 1Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Cytokine
|July 6, 2023
PubMed

Insights

Cytokines, immune system components, are key biomarkers for cardiovascular diseases (CVDs). This review highlights interleukins (ILs) roles in diagnosing and predicting CVDs, aiding in inflammation and atherosclerosis research.

Area of Science:

  • Biochemistry
  • Immunology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) present a significant global health burden.
  • Established biomarkers like cardiac troponin (cTn) and NT-proBNP are crucial for CVD evaluation.
  • Cytokines, integral to immune responses, significantly influence CVD pathogenesis through inflammation.

Purpose of the Study:

  • To review current evidence on cytokine roles in cardiovascular diseases.
  • To identify specific cytokines as potential diagnostic and prognostic biomarkers for CVDs.
  • To elucidate the dual role of interleukins in inflammation and atherosclerosis.

Main Methods:

  • Comprehensive literature search for recent studies on cytokines and CVDs.
  • Analysis of cytokine expression patterns in various cardiovascular conditions.
  • Synthesis of data linking specific cytokines to disease progression and outcomes.

Main Results:

  • Elevated levels of IL-1α, IL-18, IL-33, IL-6, and IL-8 correlate with atherosclerosis.
  • Certain interleukins, such as IL-35, show negative correlation with acute myocardial infarction and cardiac angina.
  • The IL-1 super family and specific IL-10 family members (IL-20, IL-10, IL-19) exhibit distinct roles in atherosclerosis.

Conclusions:

  • Cytokines represent promising diagnostic and prognostic biomarkers for CVDs.
  • Understanding cytokine profiles can enhance CVD risk stratification and management.
  • Targeting specific cytokines may offer novel therapeutic strategies for cardiovascular conditions.

Keywords:
AtherosclerosisCardiovascular diseaseInterleukin-1Interleukins

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