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Updated: Jul 24, 2025
09:56
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
669
mRNA: A promising platform for cancer immunotherapy
Byoungjae Kong1, Yelee Kim2, Eun Hye Kim2
1Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Advanced Drug Delivery Reviews
|July 6, 2023
Summary
Messenger RNA (mRNA) therapeutics show great promise for cancer immunotherapy, leveraging advancements in nanoformulation delivery. This review covers current strategies and future prospects for mRNA-based cancer treatments.
Area of Science:
- Biotechnology
- Immunology
- Oncology
Background:
- Messenger RNA (mRNA) technology has emerged as a significant therapeutic tool, particularly for treating malignant tumors.
- The success of mRNA vaccines in the COVID-19 pandemic has spurred interest in their application for cancer immunotherapy.
- Advancements in mRNA and nanoformulation delivery systems are crucial for realizing the potential of mRNA therapeutics.
Purpose of the Study:
- To provide a comprehensive overview of mRNA-based therapeutics for cancer immunotherapy.
- To highlight the current state and future prospects of mRNA technology in oncology.
- To discuss various therapeutic modalities and delivery strategies for mRNA in cancer treatment.
Main Methods:
- Review of recent preclinical and clinical results in mRNA-based cancer therapy.
- Analysis of different therapeutic modalities including cancer vaccines, adoptive T-cell therapies, therapeutic antibodies, and immunomodulatory proteins.
- Examination of nanoformulation-based delivery technologies for mRNA.
Main Results:
- mRNA therapeutics demonstrate tremendous potential in cancer immunotherapy.
- Various mRNA-based therapeutic modalities are being developed for cancer treatment.
- Successful delivery systems are key to the efficacy of mRNA-based cancer therapies.
Conclusions:
- mRNA technology is a powerful and versatile platform for developing novel cancer immunotherapies.
- Continued advancements in delivery systems will enhance the clinical application of mRNA therapeutics.
- mRNA-based strategies offer a promising future for treating various human diseases, especially malignant tumors.
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