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Updated: Jul 24, 2025
08:20
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
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Functional MRI markers for treatment-resistant depression: Insights and challenges
Vasileia Kotoula1, Jennifer W Evans1, Claire Punturieri1
1Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, United States.
Progress in Brain Research
|July 6, 2023
Summary
Neuroimaging reveals altered brain connectivity and metabolites in treatment-resistant depression (TRD). Interventions like TMS show promise in reversing these changes, but more research is needed for definitive conclusions.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Treatment-resistant depression (TRD) poses a significant clinical challenge.
- Understanding the neurobiological underpinnings of TRD is crucial for developing effective treatments.
Purpose of the Study:
- To provide an overview of neuroimaging findings in TRD.
- To identify potential therapeutic targets based on brain alterations.
Main Methods:
- Review of studies utilizing structural magnetic resonance imaging (MRI), functional MRI (fMRI), and magnetic resonance spectroscopy (MRS).
Main Results:
- Consistent findings suggest decreased frontal brain connectivity and altered metabolite concentrations in TRD.
- Some interventions, such as transcranial magnetic stimulation (TMS), may reverse these neuroimaging changes.
Conclusions:
- Neuroimaging highlights potential pathophysiological mechanisms in TRD.
- Larger, standardized studies and data sharing are essential to advance TRD research and identify novel treatment targets.
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