The association between prediabetes and bone mineral density: A meta-analysis

Area of Science:

• Endocrinology
• Metabolic Health
• Bone Health

Background:

• Prediabetes represents a metabolic state between normal glucose levels and type 2 diabetes.
• It is defined by impaired fasting glucose, impaired glucose tolerance, or elevated HbA1c (5.7%-6.4%).
• The impact of prediabetes on bone mineral density (BMD) remains unclear.

Purpose of the Study:

• To conduct a meta-analysis evaluating the association between prediabetes and BMD.
• To synthesize existing evidence on prediabetes and its effects on bone health.

Main Methods:

• A systematic literature search was performed across PubMed, Web of Science, and Embase databases (January 1990 - December 2022).
• Data were analyzed using a random-effects model, with heterogeneity assessed by I² statistic.
• Meta-regression was employed for subgroup analyses based on pre-defined variables.

Main Results:

• The meta-analysis included 17 studies with 45,788 participants.
• Prediabetes was significantly associated with increased BMD in the spine, femur neck, and total femur.
• Subgroup analyses revealed stronger associations in men, Asians, and individuals over 60 years old.

Conclusions:

• Prediabetes is strongly associated with elevated BMD in the spine, femur neck, and total femur.
• This association is more pronounced in specific demographic groups: males, Asians, and older adults (>60 years).
• Further research may explore the clinical implications of these findings.