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Management of Stroke in Patients With Chronic Liver Disease: A Practical Review

Neal S Parikh1, Elora Basu, Mu Ji Hwang2

  • 1Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology (N.S.P., E.B., S.B.M., H.K.), Weill Cornell Medicine, New York, NY.

Stroke
|July 7, 2023
PubMed

Insights

Chronic liver disease (CLD) significantly impacts stroke risk and outcomes. This review synthesizes current data on CLD

Area of Science:

  • Neurology
  • Hepatology
  • Vascular Medicine

Background:

  • Chronic liver disease (CLD) is common and can have subclinical manifestations.
  • CLD causes systemic issues like coagulopathy and altered drug metabolism, relevant to stroke.
  • Existing stroke guidelines offer limited information on managing patients with CLD.

Purpose of the Study:

  • To provide vascular neurologists with a contemporary overview of CLD.
  • To review the impact of CLD on stroke risk, mechanisms, and outcomes.
  • To discuss acute and chronic treatment strategies for stroke patients with CLD.

Main Methods:

  • Multidisciplinary literature review.
  • Synthesis of data on CLD and stroke intersection.
  • Appraisal of evidence regarding CLD's influence on stroke.

Main Results:

  • CLD presents systemic aberrations that affect stroke risk.
  • Specific data on CLD's impact on stroke incidence, mechanisms, and prognosis are emerging.
  • Treatment considerations for stroke in CLD patients require tailored approaches.

Conclusions:

  • CLD is an important factor to consider in stroke patients.
  • Further research and guideline development are needed for this population.
  • A multidisciplinary approach is crucial for managing stroke in individuals with CLD.

Keywords:
cerebrovascular disordersliver diseasesstroke

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