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Updated: Jul 24, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Elemental Sulfur-Mediated Synthesis of Quinoxalines from Sulfoxonium Ylides
Trayambek Nath Chaubey1, Paran J Borpatra1, Satyendra Kumar Pandey1
1Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Abstract:
A novel straightforward and catalyst-free approach for synthesizing quinoxaline derivatives from sulfoxonium ylides and o-phenylenediamines mediated by elemental sulfur has been described. Due to the simple and mild reaction conditions, the sulfoxonium ylides and o-phenylenediamines decorated with different functional groups furnished moderate to high yields of quinoxaline derivatives and were well tolerated. Finally, large-scale reactions, the synthesis of pyrazines, and some bioactive compounds are used to illustrate the potential utility of the developed approach.
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