Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial intelligence in urological education: a systematic review.

BMC medical education·2026
Same author

Soluble dietary fiber from Piper sarmentosum Roxb. leaves modulates gut microbiota-derived cis-11-eicosenoic acid to regulate lipid metabolism.

International journal of biological macromolecules·2026
Same author

Fibrillar Hydrogel Derived from Nanocellulose and a Synthetic Polypeptide.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Talquetamab: Mechanism of Action, Clinical, and Translational Science.

Clinical and translational science·2026
Same author

Synergistic Mechanisms and Product Regulation in the Co-Pyrolysis of Biomass and Food Packaging Waste: A Study Based on Reaction Kinetics and GHG Calculation.

Foods (Basel, Switzerland)·2026
Same author

Therapeutic Strategies and Clinical Outcomes of Infections Following Anterior Cruciate Ligament Reconstruction: A Narrative Review.

Orthopaedic surgery·2026

Related Experiment Video

Updated: Jul 24, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.5K

Self-Immolative Hydrogels with Stimulus-Mediated On-Off Degradation.

Jue Gong1, Aneta Borecki1, Elizabeth R Gillies1,2

  • 1Department of Chemistry, The University of Western Ontario, 1151 Richmond St., London, Ontario N6A 5B7, Canada.

Biomacromolecules
|July 7, 2023
PubMed
Summary

New self-immolative polymer hydrogels offer precise control for smart materials. These light-responsive materials demonstrate tunable degradation and drug release, advancing applications in sensors and drug delivery.

More Related Videos

Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications
10:45

Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications

Published on: September 29, 2016

13.1K
Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.2K

Related Experiment Videos

Last Updated: Jul 24, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.5K
Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications
10:45

Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications

Published on: September 29, 2016

13.1K
Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.2K

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Hydrogels are versatile materials for applications like drug delivery and tissue engineering.
  • Self-immolative polymers offer cascade degradation and stimulus-tunable properties.
  • Existing self-immolative hydrogels have limitations in stability and degradation speed.

Purpose of the Study:

  • To prepare and characterize novel self-immolative polymer hydrogels.
  • To investigate the stimulus-responsive degradation and drug release capabilities.
  • To address limitations of previous self-immolative hydrogel systems.

Main Methods:

  • Synthesis of hydrogels using self-immolative poly(ethyl glyoxylate) (PEtG) and poly(ethylene glycol) (PEG).
  • Incorporation of a light-responsive linker end-cap for controlled degradation.
  • Evaluation of hydrogel properties including gel content, water content, and compressive modulus.
  • Assessment of repeated on/off degradation cycles and controlled drug release (celecoxib).

Main Results:

  • Hydrogels exhibited high gel content (90%), equilibrium water content (89%), and a compressive modulus of 26 kPa.
  • Degradation was repeatedly controlled by alternating light irradiation and dark storage.
  • Controlled release of the anti-inflammatory drug celecoxib was achieved through light-triggered degradation cycles.

Conclusions:

  • The developed self-immolative hydrogels demonstrate excellent stability and tunable degradation.
  • These materials offer precise control over stimulus-response, suitable for advanced applications.
  • The findings highlight the potential of self-immolative hydrogels in smart materials for drug delivery and sensing.