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Remote HbA1c testing via microsampling: fit for purpose?

Nick Verougstraete1,2, Veronique Stove2,3, Christophe P Stove1

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Clinical Chemistry and Laboratory Medicine
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Summary

Finger-prick blood microsampling offers a convenient, patient-centric method for remote diabetes monitoring using HbA1c analysis. This review critically examines microsampling techniques for reliable results, enhancing patient care.

Keywords:
HbA1cdried blood microsamplingliquid blood microsamplingmicrosampling

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Area of Science:

  • Clinical Chemistry and Laboratory Medicine
  • Endocrinology and Diabetes Management
  • Point-of-Care Testing

Background:

  • Traditional venipuncture for blood collection presents logistical challenges, particularly for remote patient monitoring.
  • Finger-prick capillary blood microsampling offers a convenient, patient-centric alternative for home-based sample collection.
  • Hemoglobin A1c (HbA1c) is a key biomarker for diabetes diagnosis and management, requiring accurate and accessible measurement.

Purpose of the Study:

  • To critically review and overview existing literature on HbA1c determination using capillary blood microsamples.
  • To identify key considerations for implementing reliable microsampling techniques for remote HbA1c monitoring.
  • To discuss the potential of both dried and liquid blood microsampling for diabetes management.

Main Methods:

  • Comprehensive literature review of studies employing capillary blood microsampling for HbA1c analysis.
  • Critical evaluation of methodologies including microsampling techniques, collection conditions, and sample stability.
  • Analysis of analytical methods, validation strategies, correlation with venous blood, and patient satisfaction.

Main Results:

  • Significant heterogeneity exists in study designs and data evaluation across published microsampling research.
  • Key factors influencing reliability include microsampling technique, collection conditions, and sample stability.
  • Both dried and liquid blood microsampling show promise for remote HbA1c analysis, with liquid microsampling emerging as a viable alternative.

Conclusions:

  • Capillary blood microsampling, particularly for HbA1c, presents a promising avenue for improved remote diabetes care and telemedicine integration.
  • Standardization of study designs and rigorous validation are crucial for widespread implementation of microsampling techniques.
  • Further research into liquid blood microsampling may offer enhanced convenience and accuracy for remote patient monitoring.