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Engineering considerations of iPSC-based personalized medicine
Sangbae Park1,2,3,4, Yonghyun Gwon1,2,3, Shahidul Ahmed Khan1,2,3
1Department of Convergence Biosystems Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
Biomaterials Research
|July 7, 2023
Summary
Engineering strategies are crucial for overcoming limitations in induced pluripotent stem cells (iPSCs) for personalized medicine. This review details advancements in iPSC production, engineering, and clinical applications for tailored therapies.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Personalized Medicine
Background:
- Personalized medicine requires tailored treatments based on individual patient characteristics.
- Induced pluripotent stem cells (iPSCs) show promise for personalized medicine but have limitations.
- Engineering strategies are needed to enhance iPSC utility in clinical settings.
Purpose of the Study:
- To review engineering strategies for advancing iPSC-based personalized medicine.
- To categorize iPSC development into production, engineering, and clinical application stages.
- To highlight the implications of engineering approaches at each developmental step.
Main Methods:
- Literature review focusing on engineering strategies in iPSC development.
- Categorization of iPSC-based personalized medicine into three key steps: production, engineering, and clinical application.
- Analysis of engineering approaches and their impact on iPSC therapeutic potential.
Main Results:
- Engineering strategies address inherent limitations of iPSCs.
- Advances in iPSC production, engineering, and clinical translation are detailed.
- Specific engineering approaches offer solutions for iPSC preparation and application.
Conclusions:
- Engineering strategies are vital for realizing the full potential of iPSCs in personalized therapy.
- Overcoming iPSC limitations through engineering paves the way for innovative clinical solutions.
- This review provides a framework for understanding the role of engineering in iPSC-based personalized medicine.
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