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TACI and endogenous APRIL in B cell maturation

Yolanda Garcia-Carmona1, Miguel Fribourg2, Allison Sowa3

  • 1Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA.

Clinical Immunology (Orlando, Fla.)
|July 8, 2023
PubMed
Summary

The TACI-S protein isoform is crucial for terminal B cell differentiation into plasma cells. Intracellular TACI-S, BCMA, and APRIL collaborate to direct this process and ensure plasma cell survival.

Keywords:
A proliferation inducing ligand (APRIL)BCMA (B cell maturation antigen)Plasma cellTACI (transmembrane activator and CAML interactor)

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