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Updated: Jul 24, 2025

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The relationship between aspirin consumption and hepatocellular carcinoma: a systematic review and meta-analysis

Shuai Wang1, Lijuan Zuo2, Zhaojin Lin3

  • 1Department of Gastroenterology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, Jilin, China.

European Journal of Medical Research
|July 8, 2023
PubMed

Insights

Aspirin consumption significantly lowers the risk of hepatocellular carcinoma (HCC) by 30%. This benefit applies to both healthy individuals and those with chronic liver disease, though gastrointestinal bleeding risks should be monitored.

Area of Science:

  • Hepatology
  • Oncology
  • Gastroenterology

Background:

  • Recent studies suggest a potential link between aspirin use and reduced risk of hepatocellular carcinoma (HCC).
  • The precise correlation between aspirin consumption and HCC incidence requires further investigation.

Conclusions:

  • Aspirin consumption is associated with a reduced risk of HCC in both the general population and individuals with chronic liver disease.
  • Caution is advised regarding potential adverse events, particularly gastrointestinal bleeding, in patients with chronic liver disease undertaking aspirin therapy.
Abstract

Keywords:
AspirinHepatocellular carcinomaMeta-analysis

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