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Updated: Jul 24, 2025

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
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Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

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The potential of cross-linking mass spectrometry in the development of protein-protein interaction modulators

Max Ruwolt1, Ilaria Piazza2, Fan Liu3

  • 1Department of Structural Biology, Leibniz, Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany.

Current Opinion in Structural Biology
|July 9, 2023
PubMed

Keywords:
Cross-linkingMass spectrometryPPI modulatorPROTACProtein–protein interactions

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