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Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder
Çetin Turan1, Güliz Şenormancı1, Salim Neşelioğlu2
1Department of Psychiatry, University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Summary
Methamphetamine use disorder (MUD) is linked to increased oxidative stress biomarkers, including thiol/disulfide imbalance and ischemia-modified albumin. Complete blood count (CBC) parameters also indicate higher systemic inflammation in MUD patients compared to controls.
Area of Science:
- Biochemistry
- Clinical Medicine
- Toxicology
Background:
- Methamphetamine (METH) use disorder (MUD) is a significant public health concern.
- Oxidative stress and systemic inflammation are implicated in METH's pathophysiology.
- Biomarkers for oxidative stress and inflammation require further investigation in MUD.
Purpose of the Study:
- To compare blood serum levels of oxidative stress and systemic inflammation biomarkers between individuals with MUD and a control group (CG).
- To assess serum thiol/disulfide balance and ischemia-modified albumin for oxidative stress.
- To evaluate serum interleukin-6 (IL-6) levels and complete blood count (CBC) for inflammation.
Main Methods:
- Fifty MUD patients and 36 CG participants provided venous blood samples.
- Serum thiol/disulfide balance, ischemia-modified albumin, and IL-6 levels were measured.
- CBC parameters and correlations with sociodemographic data were analyzed.
Main Results:
- MUD patients exhibited significantly higher serum total thiol, free thiol, and ischemia-modified albumin levels compared to CG.
- No significant differences were found in serum disulfide or IL-6 levels between groups.
- Inflammatory parameters in CBC were significantly elevated in MUD patients, with duration of use correlating with IL-6.
Conclusions:
- Complete blood count (CBC) effectively assesses systemic inflammation in MUD.
- Thiol/disulfide homeostasis and ischemia-modified albumin serve as reliable indicators of oxidative stress in MUD.
