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Investigating Angiographic Injection Parameters for Cerebral Aneurysm Hemodynamic Characterization Using

R White1, A Shields2,3, S V Nagesh2,3

  • 1Biomedical Engineering, Florida Institute of Technology, State University of New York at Buffalo.

Proceedings of Spie--The International Society for Optical Engineering
|July 10, 2023
PubMed
Summary
This summary is machine-generated.

Simulated angiograms quantify blood flow in cerebral aneurysms (CA) during endovascular therapy. This method provides crucial hemodynamic data, improving treatment insights for hemorrhagic stroke.

Keywords:
Angiographic AnalysisAngiographic Parametric Imaging (API)Cerebral AneurysmComputational Fluid Dynamics (CFD)HemodynamicsSimulated AngiogramsTime Density Curve

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Computational Fluid Dynamics

Background:

  • Cerebral aneurysm rupture is a leading cause of hemorrhagic stroke.
  • Endovascular therapy lacks quantitative hemodynamic data during procedures.
  • In vivo quantification of angiographic sequences is challenging.

Purpose of the Study:

  • To quantify hemodynamic interactions with contrast agents using simulated angiograms (SA).
  • To analyze hemodynamic parameters like time to peak (TTP) and mean transit time (MTT) in cerebral aneurysms.
  • To evaluate the impact of variable contrast injection parameters on hemodynamic quantification.

Main Methods:

  • Utilized computational fluid dynamics (CFD) to create simulated angiograms (SA).
  • Extracted time density curves (TDC) from SA to analyze hemodynamic parameters.
  • Simulated 7 patient-specific cerebral aneurysm geometries with varying contrast injection scenarios.

Main Results:

  • SA enabled quantification of hemodynamic parameters in patient-specific cerebral aneurysm models.
  • Identified prolonged contrast circulation within aneurysms, particularly larger or tortuous ones.
  • Demonstrated the ability to determine angiographic parameters under varied injection conditions.

Conclusions:

  • SA provides a viable method to overcome limitations of in vitro/in vivo angiographic quantification.
  • This approach offers valuable hemodynamic insights for cerebral aneurysm treatment planning.
  • The methodology can enhance understanding of vascular morphology and contrast flow dynamics.