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Capturing Actively Produced Microbial Volatile Organic Compounds from Human-Associated Samples with Vacuum-Assisted Sorbent Extraction
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Proteomic associations with forced expiratory volume - a Mendelian randomisation study.
Medrxiv : the Preprint Server for Health Sciences
|July 10, 2023
Summary
This study identified protein biomarkers linked to lung function decline, specifically forced expiratory volume (FEV1). Several proteins, including Thrombospondin 2 (THBS2), show potential causal roles in respiratory health.
Area of Science:
- Pulmonary Medicine
- Proteomics
- Genetics
Background:
- Obstructive respiratory diseases are a major cause of morbidity in the elderly, characterized by declining lung function (FEV1).
- Understanding biomarkers associated with FEV1 is crucial for managing these conditions.
Conclusions:
- Large-scale proteogenomic analysis reveals novel protein markers associated with FEV1.
- Identified several proteins, notably THBS2, with potential causal roles in regulating lung function.
- Findings contribute to understanding the molecular basis of obstructive respiratory diseases and lung function.
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