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Updated: Jul 24, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Rituximab for linear immunoglobulin A bullous dermatosis
Rummit Dhillon1, Lily Park1, Sarah Gabros1
1Department of Dermatology, Larkin Community Hospital, Miami, FL, USA.
Abstract:
Linear immunoglobulin A bullous dermatosis (LABD) is an idiopathic or drug-induced vesiculobullous disease typically managed with dapsone or colchicine. We report a case of LABD successfully treated with rituximab in a patient who was intolerant to first-line therapies and recalcitrant to typical immunosuppressants. The patient was initially started on prednisone and mycophenolate mofetil which resulted in minimal response and disease progression. Improvement was seen after two infusions of rituximab 1000 mg at 2 weeks apart with planned maintenance therapy.
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