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Related Experiment Video

Updated: Jul 24, 2025

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

HyenaDNA: Long-Range Genomic Sequence Modeling at Single Nucleotide Resolution.

Eric Nguyen, Michael Poli, Marjan Faizi

|July 10, 2023

Summary

HyenaDNA, a new genomic foundation model, processes DNA sequences at single nucleotide resolution with unprecedented long-context capabilities. This model achieves state-of-the-art performance on multiple benchmarks, outperforming previous methods significantly.

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Related Experiment Videos

Last Updated: Jul 24, 2025

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

Analyzing and Building Nucleic Acid Structures with 3DNA

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Area of Science:

Genomics
Computational Biology
Machine Learning

Background:

Genomic sequences contain vast information for gene regulation and protein synthesis.
Foundation models in genomics aim to learn generalizable features from unlabeled genome data.
Previous Transformer-based models had limited context length (4k tokens) and lost single nucleotide resolution.

Conclusions:

HyenaDNA significantly advances genomic sequence modeling through extended context and single nucleotide resolution.
The model offers superior performance with fewer parameters and less pretraining data.
HyenaDNA unlocks new possibilities in genomics, including in-context learning.