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Lipid polymorphism.

C P Tilcock

    Chemistry and Physics of Lipids
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Biological membrane lipids can form various non-lamellar phases influenced by temperature, ions, and pH. Cholesterol significantly impacts these lipid polymorphism behaviors in mixed systems.

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    Area of Science:

    • Biochemistry
    • Biophysics
    • Membrane Biology

    Background:

    • Biological membranes are composed of diverse lipid classes.
    • Lipids exhibit complex polymorphic phase behaviors crucial for membrane function.
    • Understanding lipid phase transitions is key to comprehending membrane dynamics.

    Purpose of the Study:

    • To review the polymorphic phase behavior of major biological membrane lipids.
    • To emphasize the factors influencing non-lamellar phase adoption by lipids.
    • To detail the effects of cholesterol on lipid polymorphism in mixed systems.

    Main Methods:

    • Literature review of lipid polymorphic phase behavior.
    • Analysis of factors affecting lipid phase preferences (temperature, cations, pH).

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  • Examination of mixed lipid systems, focusing on cholesterol's influence.

    • Main Results:

    • Many membrane lipids can adopt non-lamellar phases.
    • Phase behavior is sensitive to environmental factors like temperature, divalent cations, and pH.
    • Cholesterol plays a significant role in modulating phase preferences in mixed lipid systems.

    Conclusions:

    • Membrane lipid polymorphism is a dynamic property influenced by multiple factors.
    • Non-lamellar phases are common and adaptable lipid structures.
    • Cholesterol is a key modulator of lipid phase behavior in biological membranes.