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Updated: Jul 24, 2025
08:14
A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
Published on: August 28, 2018
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Pleiotropy of PCSK9: Functions in Extrahepatic Tissues
Yusuf Ziya Şener1, Lale Tokgözoğlu2
1Cardiology Department, Beypazarı State Hospital, Ankara, Turkey. yzsener@yahoo.com.tr.
Current Cardiology Reports
|July 10, 2023
Summary
Proprotein convertase subtilisin/kexin type 9 (PCSK9) impacts heart, brain, and kidney functions beyond cholesterol metabolism. PCSK9 inhibitors show beneficial or neutral effects on these organs, with no link to new-onset diabetes in real-world data.
Area of Science:
- Cardiovascular Science
- Nephrology
- Neurology
Background:
- Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily known for its role in LDL receptor metabolism in the liver.
- Emerging evidence highlights PCSK9's involvement in diverse physiological functions across multiple organs.
Purpose of the Study:
- To review and summarize the extraliver functions of PCSK9.
- To explore the implications of PCSK9's extraliver roles in the context of PCSK9 inhibitor therapy.
Main Methods:
- Literature review of studies investigating PCSK9's functions in non-hepatic tissues.
- Analysis of clinical data regarding the effects of PCSK9 inhibitors on cardiac, renal, and neurological outcomes.
Main Results:
- PCSK9 plays significant roles in cardiac, renal, and neurological systems.
- PCSK9 inhibitors demonstrate beneficial or neutral effects on these organs.
- While experimental studies suggested a link between PCSK9 inhibition and new-onset diabetes, real-world data show no such association.
Conclusions:
- Understanding PCSK9's extraliver functions is crucial for optimizing PCSK9 inhibitor therapy.
- PCSK9 inhibition appears safe and potentially beneficial for cardiovascular, renal, and neurological health.
- PCSK9 may represent a future therapeutic target for conditions like nephrotic syndrome and heart failure.
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