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Related Experiment Video

Updated: Jul 24, 2025

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
10:10

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

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Image-based flow simulation of platelet aggregates under different shear rates.

Yue Hao1, Gábor Závodszky1,2, Claudia Tersteeg3

  • 1Computational Science Lab, Informatics Institute, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.

Plos Computational Biology
|July 10, 2023
PubMed
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This study introduces a new computational model to simulate blood flow around platelet aggregates. The model reveals how aggregate microstructure and shear rate influence agonist transport and aggregate shape, improving understanding of platelet aggregation dynamics.

Area of Science:

  • Biomedical Engineering
  • Computational Fluid Dynamics
  • Hematology

Background:

  • Platelet activation and aggregation are critical in hemostasis and thrombosis, heavily influenced by blood flow dynamics.
  • Understanding the hemodynamics within and around platelet aggregates is essential for predicting thrombotic events.

Purpose of the Study:

  • To develop and validate a novel image-based computational model for simulating blood flow through platelet aggregates.
  • To investigate the influence of aggregate microstructure and shear rate on hemodynamics and agonist transport within platelet aggregates.

Main Methods:

  • Utilized microscopy images to define platelet aggregate geometry and internal density.
  • Modeled aggregates as porous media, calculating permeability using the Kozeny-Carman equation.

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Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
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Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

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Related Experiment Videos

Last Updated: Jul 24, 2025

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
10:10

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

18.2K
Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
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Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

11.7K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

956
  • Applied computational fluid dynamics to analyze blood flow, shear stress, and kinetic forces at varying wall shear rates (800, 1600, 4000 s⁻¹).

    • Main Results:

    • Agonist transport is significantly affected by both shear rate and aggregate microstructure.
    • High kinetic forces were observed at the shell-core transition zone of aggregates.
    • Aggregate shape and elongation are strongly correlated with shear rate and elongation flow rate.

    Conclusions:

    • The developed framework integrates aggregate microstructure into computational models for enhanced understanding of platelet aggregation.
    • Findings provide a foundation for predicting platelet aggregation and deformation under diverse hemodynamic conditions.