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Comparative y-Narratives Inscribed Throughout Genomes of Man and Dog
Havard R Glattre1, Eystein Glattre1, Lars Moe1
1Norwegian School of Veterinary Science, NMBU, Oslo, Norway.
Nonlinear Dynamics, Psychology, and Life Sciences
|July 10, 2023
Summary
Researchers discovered numerous hidden y-texts within both the genetic and non-protein-coding DNA of humans and dogs. These texts, found in exons and non-coding regions, may influence cellular behavior and disease etiology.
Area of Science:
- Genomics
- Bioinformatics
- Molecular Biology
Background:
- Previous research focused on non-protein-coding (npc) DNA for hidden y-texts.
- Y-texts are sequences of nucleotides (A, C, G, T) delimited by stop-codons.
- The y-text-finder tool was developed to identify these sequences.
Purpose of the Study:
- To analyze the entire human and canine genomes, dividing them into genetic (exons) and non-protein-coding regions.
- To quantify zipf-qualified and a-qualified y-texts within these genomic divisions.
- To investigate the overlap between identified y-texts and genes.
Main Methods:
- Application of the y-text-finder tool to analyze the whole human (Homo sapiens sapiens) and canine (Canis lupus familiaris) genomes.
- Division of the genome into genetic (exons) and non-protein-coding fractions.
- Identification and quantification of zipf-qualified and a-qualified y-texts in each fraction.
Main Results:
- Significant numbers of y-texts were found in both the genetic (exons) and non-protein-coding genome fractions of both species.
- A non-negligible quantity of y-texts was identified within the exon sequences.
- Numerous genes were found to be included in or overlap with zipf-qualified and a-qualified y-texts.
Conclusions:
- The human and canine genomes contain extensive y-texts in both coding and non-coding regions.
- These findings suggest a broader role for y-texts in genomic information beyond protein-coding sequences.
- The presence of y-texts may be relevant to understanding cellular behavior, disease etiology, and carcinogenesis.
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