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Related Concept Videos

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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Ion Channels01:19

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The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
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Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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The Quantum-Mechanical Model of an Atom02:45

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Shortly after de Broglie published his ideas that the electron in a hydrogen atom could be better thought of as being a circular standing wave instead of a particle moving in quantized circular orbits, Erwin Schrödinger extended de Broglie’s work by deriving what is now known as the Schrödinger equation. When Schrödinger applied his equation to hydrogen-like atoms, he was able to reproduce Bohr’s expression for the energy and, thus, the Rydberg formula governing hydrogen spectra.
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The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
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Non-gated Ion Channels01:24

Non-gated Ion Channels

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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Related Experiment Video

Updated: Jul 24, 2025

Recapitulation of an Ion Channel IV Curve Using Frequency Components
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Recapitulation of an Ion Channel IV Curve Using Frequency Components

Published on: February 8, 2011

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Quantum mechanics in ion channel.

Yuval Ben-Abu1

  • 1Physics Unit, Sapir Academic College, Hof Ashkelon, Sderot 79165, Israel.

Biophysical Chemistry
|July 10, 2023
PubMed
Summary

This study explores ion channel dynamics using quantum mechanics, proposing a novel approach to analyze ion transit times between gate structures. It aims to bridge the gap in quantum mechanical analogs for biological systems.

Area of Science:

  • Biophysics
  • Quantum Mechanics
  • Systems Biology

Background:

  • Existing research links physical systems to systems biology with impressive analogs.
  • Quantum mechanics currently has limited data and knowledge regarding biological system analogs.
  • Ion movement in biological systems often exhibits negligible time periods and approximately constant velocity.

Purpose of the Study:

  • To investigate ion channel behavior through the lens of quantum mechanics.
  • To introduce a new perspective on ion channel function by applying quantum mechanical principles.
  • To analyze the time required for ion transit across ion channel gates.

Main Methods:

  • Application of quantum mechanical principles to ion channel models.
  • Theoretical analysis of ion movement dynamics within a defined channel structure.

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Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay
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Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay

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Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
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Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay
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  • Calculation of ion transit time across a specific distance between two gates.

    • Main Results:

    • A theoretical framework for analyzing ion channel gating using quantum mechanics was developed.
    • The study provides a method to estimate ion transit time, considering quantum effects.
    • Identified potential for novel insights into ion transport mechanisms.

    Conclusions:

    • Quantum mechanics offers a promising, yet underexplored, avenue for understanding ion channel function.
    • This research lays the groundwork for future studies integrating quantum phenomena into ion channel analysis.
    • The proposed model can enhance our understanding of biological transport processes at a fundamental level.