Therapeutic Potential and Molecular Mechanisms of the Multitargeted Flavonoid Fisetin

Area of Science:

• Dietary compounds
• Natural products pharmacology
• Oncology

Background:

• Flavonoids exhibit therapeutic potential for cancer, inflammation, and oxidative stress.
• Fisetin, a plant-derived flavonoid, demonstrates anti-cancer properties by influencing cell cycle and angiogenesis.
• Cancer remains a leading global cause of mortality, necessitating novel therapeutic strategies.

Approach:

• This review synthesizes current research on fisetin's molecular functions and pharmacological activities.
• Focuses on fisetin's efficacy in preclinical models against various chronic conditions, including cancer, metabolic, and neurological disorders.
• Highlights the potential of fisetin as a dietary component for disease prevention and treatment.

Key Points:

• Fisetin effectively suppresses cancer cell proliferation and angiogenesis without harming healthy cells.
• The compound exhibits broad pharmacological activities, including potential applications in diabetes, obesity, allergies, and neurological conditions.
• Research underscores fisetin's role in combating chronic diseases through its molecular mechanisms.

Conclusions:

• Fisetin holds significant potential for cancer prevention and treatment due to its targeted anti-cancer effects.
• Further clinical investigations in humans are warranted to validate fisetin's efficacy across diverse cancer types.
• Fisetin's multifaceted pharmacological activities suggest its utility in managing a spectrum of chronic diseases.