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Altered tissue oxygen tension responsiveness in diabetes
Diabetes Research and Clinical Practice
|June 1, 1986
Summary
Tissue oxygen levels (PO2) are altered in insulin-dependent diabetes mellitus (IDDM). Diabetic patients showed reduced PO2 recovery after arterial occlusion and diminished PO2 increase during hyperemia compared to controls.
Area of Science:
- Physiology
- Diabetology
- Vascular Biology
Background:
- Insulin-dependent diabetes mellitus (IDDM) is associated with microvascular complications.
- Peripheral tissue oxygenation may be impaired in individuals with IDDM.
Purpose of the Study:
- To investigate subcutaneous oxygen tension (tissue PO2) responses in the legs of IDDM patients.
- To compare tissue PO2 dynamics during ischemia and hyperemia between IDDM patients and healthy controls.
Main Methods:
- Polarographic measurement of subcutaneous tissue PO2 in the legs.
- A five-stage protocol including arterial occlusion and reactive hyperemia induction via local heat application.
- Comparison between 11 IDDM patients (duration 4-32 years, no peripheral arterial disease) and 10 healthy controls.
Main Results:
- Mean baseline subcutaneous PO2 was not significantly different between groups.
- Diabetics exhibited a significantly smaller decrease in tissue PO2 during recovery from ischemia (P < 0.025).
- Diabetics showed a significantly lower increase in tissue PO2 upon hyperemia induction (P < 0.001).
Conclusions:
- Direct evidence of altered tissue PO2 responses in the legs of IDDM patients is presented.
- These findings suggest impaired microvascular function and oxygen delivery in individuals with IDDM.