Oil-gated isoporous membrane with micro-apertures for controllable pressure-induced passive flow regulator

The pressure-driven liquid flow controller is one of the key components in diverse applications including microfluidic systems, biomedical drug injection devices, and pressurized water supply systems. Electric feedback loop based flow controllers are fine-tunable but expensive and complex. The conventional safety valves based on spring force are simple and low cost, but their diverse application is limited due to their fixed pressure range, size, and shape. Herein, we propose a simple and controllable liquid-flowing system combining a closed liquid reservoir and an oil-gated isoporous membrane (OGIM). The ultra-thin and flexible OGIM acts as an immediately responsive and precisely controlled gas valve to maintain internal pneumatic pressure as designed to induce constant liquid flow. The oil filling apertures act as a gate for gas flow depending on the applied pressure and the threshold (gating) pressure of the gate is determined by the surface tension of the oil and the gate diameter. It is confirmed that the gating pressure is precisely controlled by varying the gate diameter, which agrees with the theoretically estimated pressures. Based on stably maintained pressure due to the function of OGIM, the constant liquid flow rate is achieved even with the high gas flow rate.