Related Experiment Video

Updated: Jul 23, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

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Regulatory genes in the androgen production, uptake and conversion (APUC) pathway in advanced prostate cancer

Sean McSweeney1, Hannah E Bergom2,3, Anna Prizment2,3

  • 1University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Endocrine Oncology (Bristol, England)
|July 12, 2023
PubMed

Insights

Androgen production, uptake, and conversion (APUC) genes impact prostate cancer (PC) treatment. Understanding APUC gene variants through genomic analysis can improve outcomes for metastatic castration-resistant prostate cancer (mCRPC) patients.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Androgen receptor (AR) signaling drives prostate cancer (PC) progression.
  • Metastatic castration-resistant prostate cancer (mCRPC) patients often develop resistance to standard therapies like androgen-deprivation therapy (ADT) and AR-targeted therapies (ART).
  • Genomic analyses reveal the importance of androgen production, uptake, and conversion (APUC) genes in PC.

Purpose of the Study:

  • To review the current role and genetic/genomic features of APUC genes in advanced prostate cancer.
  • To discuss how understanding APUC gene behavior impacts mCRPC treatment.
  • To highlight the actionable enzymatic activities of APUC genes.

Main Methods:

  • Genomic analyses of patient germlines.
  • Review of existing literature on APUC genes in prostate cancer.
  • Elucidation of APUC gene roles in mCRPC patient outcomes.

Main Results:

  • APUC genes are active and upregulated in mCRPC.
  • Specific genetic variants, like HSD3B1, predict response to second-generation ART.
  • APUC genes possess unique, actionable enzymatic activities.

Conclusions:

  • Interpreting APUC gene behavior via genomic tools is crucial for advancing mCRPC treatment.
  • Further research into APUC genes can personalize and optimize therapy for advanced prostate cancer.
  • Understanding genetic variations in APUC genes offers new therapeutic strategies.
Keywords:
androgensgenomicsprostate cancer

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