Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Principles of Disease Surveillance

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...

Pharmacovigilance

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

Antimicrobial Effectiveness

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editorial Comment.

The Journal of urology·2026

Same author

Symptoms and subtypes of patients with lower urinary tract dysfunction - insights from the Symptoms of Lower Urinary Tract Dysfunction Research Network.

Nature reviews. Urology·2026

Same author

DGAT1 Drives Racially Divergent Fibroblast Activation via ERK1/2-Dependent Tumorigenic Signaling in Prostate Cancer.

Cancer research communications·2026

Same author

Prostate Cancer, Genetic Susceptibility, and Risk of Chronic Non-Urological Complications.

The Prostate·2026

Same author

Development of an Integrated Monogenic and Polygenic Risk Assessment Tool for Coronary Artery Disease and Its Application in a Community-Based Health Care Biobank.

Circulation. Genomic and precision medicine·2026

Same author

An intra-patient contemporaneous comparison of <sup>18</sup>F-piflufolastat and <sup>18</sup>F-flotufolastat urinary radioactivity and pelvic region detection rates in men with low PSA biochemical recurrence of prostate cancer after radical prostatectomy.

European journal of nuclear medicine and molecular imaging·2026

Same journal

Effective Mentorship in Urology Fellowship Training: Qualities, Models, and Equity.

Current urology reports·2026

Same journal

Management of Lower Urinary Tract Symptoms in Patients With Multiple Sclerosis.

Current urology reports·2026

Same journal

Lower Urinary Tract Symptoms as an Indicator of Occult Neurologic Disease: A System-first Framework for Urologic Practice.

Current urology reports·2026

Same journal

Association Between Ambient Temperature and Urolithiasis: A Systematic Review and Meta-analysis.

Current urology reports·2026

Same journal

Is Open Partial Nephrectomy Still an Option in the Robotic Era?

Current urology reports·2026

Same journal

Artificial Intelligence in Urologic Documentation: A Review of Emerging Capabilities and the Ongoing Need for Human Oversight.

Current urology reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 23, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Is Active Surveillance Too Active?

James T Kearns¹, Brian T Helfand²

¹Division of Urology, NorthShore University HealthSystem, 2180 Pfingsten Rd., Suite 3000, Glenview, Evanston, IL, 60026, USA. jkearns@northshore.org.

Current Urology Reports

|July 12, 2023

Summary

This summary is machine-generated.

Current prostate cancer active surveillance protocols may involve excessive testing. While MRI and biomarkers aid risk stratification, periodic biopsies remain essential for safety, as omitting them is not yet proven viable.

Keywords:

Active surveillance Biomarkers Prostate MRI Prostate cancer

More Related Videos

Visualizing Efficacy of Pesticides Against Disease Vector Mosquitoes in the Field

Visualizing Efficacy of Pesticides Against Disease Vector Mosquitoes in the Field

Published on: March 16, 2019

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

Related Experiment Videos

Last Updated: Jul 23, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Visualizing Efficacy of Pesticides Against Disease Vector Mosquitoes in the Field

Visualizing Efficacy of Pesticides Against Disease Vector Mosquitoes in the Field

Published on: March 16, 2019

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

Area of Science:

Oncology
Urology
Medical Diagnostics

Background:

Active surveillance is a common strategy for managing low-risk prostate cancer.
Protocols often include frequent monitoring like PSA tests, clinic visits, MRI, and biopsies.

Purpose of the Study:

To evaluate if current prostate cancer active surveillance protocols lead to over-testing.
To assess the necessity and utility of serial monitoring components.

Main Methods:

Review of recent studies on multiparametric MRI, serum biomarkers, and serial prostate biopsies.
Analysis of the predictive value of these tools in active surveillance.

Main Results:

Multiparametric MRI and serum biomarkers show promise for risk stratification.
No evidence supports safely omitting periodic prostate biopsies in active surveillance.
Additional MRIs or biomarkers do not consistently improve prediction of higher-grade disease.

Conclusions:

Current active surveillance protocols may be overly intensive for some patients.
Periodic prostate biopsies remain a critical component of active surveillance safety.
Further research is needed to optimize monitoring strategies without compromising patient safety.