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Confronting antifungal resistance, tolerance, and persistence: Advances in drug target discovery and delivery systems

Lei Chen1, Lanyue Zhang2, Yuyan Xie2

  • 1State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

Advanced Drug Delivery Reviews
|July 12, 2023
PubMed

Insights

Antifungal drug resistance in human pathogenic fungi is a growing threat. This review highlights new drug targets and delivery systems to combat emerging fungal resistance, tolerance, and persistence for improved therapies.

Area of Science:

  • Medical Mycology
  • Antimicrobial Resistance
  • Drug Discovery

Background:

  • Human pathogenic fungi present significant health risks, complicated by increasing drug resistance.
  • Limited antifungal treatments face challenges from emerging drug-resistant fungal strains, leading to treatment failures.
  • Fungal drug tolerance and persistence are critical survival mechanisms complicating antifungal treatment efficacy.

Purpose of the Study:

  • To review recent advancements in understanding antifungal resistance, tolerance, and persistence.
  • To identify promising drug targets for novel antifungal therapies.
  • To explore innovative drug delivery systems for enhanced antifungal treatment.

Main Methods:

  • Literature review of recent studies on fungal drug response.
  • Analysis of mechanisms underlying antifungal resistance, tolerance, and persistence.
  • Evaluation of potential therapeutic targets and drug delivery strategies.

Main Results:

  • Emergence of drug-resistant fungal variants necessitates new therapeutic approaches.
  • Understanding fungal survival strategies like tolerance and persistence is crucial.
  • Promising drug targets and advanced delivery systems show potential for improved antifungal treatments.

Conclusions:

  • A deeper understanding of fungal drug response is vital for developing effective antifungal therapies.
  • Targeting resistance, tolerance, and persistence mechanisms can overcome treatment failures.
  • Novel drug targets and delivery systems offer hope for combating challenging fungal infections.
Keywords:
Antifungal persistenceAntifungal resistanceAntifungal targetsAntifungal toleranceDrug delivery system

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