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Updated: Jul 23, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
The relation of depressive symptoms to theory of mind in adults
Bridget A Nestor1, Qimin Liu2, Susanna Sutherland3
1Department of Anesthesia, Boston Children's Hospital, Harvard Medical School, United States of America; Department of Psychology and Human Development, Vanderbilt University, United States of America.
Background:
Theory of mind (ToM) is the ability to understand thoughts and feelings of others. Significant heterogeneity exists for the strength of the association between depression and ToM performance.
Methods:
To clarify these relations, two studies of depressed and nondepressed adults investigate cross-sectional associations of four latent depression factors (i.e., somatic symptoms, depressed affect, positive affect, and interpersonal problems) to two aspects of ToM (reasoning vs. decoding). Study 1 investigated associations between depression factors and reasoning ToM (N = 258), and Study 2 investigated associations between depression factors and decoding ToM (N = 219).
Results:
In Study 1, the interpersonal problems factor was negatively related to reasoning ToM, though in Study 2, no consistent associations emerged between depression and decoding ToM. Study 2 also replicated a novel approach to assessing valence with the Reading the Mind in the Eyes Test.
Limitations:
This investigation was primarily limited by cross-sectional designs, self-report, and online delivery of measures.
Conclusions:
Findings emphasize the heterogeneity of ToM as a construct and identify targets for clinical intervention, with specific focus on bolstering reasoning ToM skills.
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