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Updated: Jul 23, 2025

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
Physiologic Markers of Disease Severity in ARDS
Joao F F M Ferraz1, Matthew T Siuba2, Sudhir Krishnan2
1Department of Hospital Medicine, Community Care Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio.
Abstract:
Despite its significant limitations, the PaO /FIO remains the standard tool to classify disease severity in ARDS. Treatment decisions and research enrollment have depended on this parameter for over 50 years. In addition, several variables have been studied over the past few decades, incorporating other physiologic considerations such as ventilation efficiency, lung mechanics, and right-ventricular performance. This review describes the strengths and limitations of all relevant parameters, with the goal of helping us better understand disease severity and possible future treatment targets.
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