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Use of Enzymatic Biosensors to Quantify Endogenous ATP or H2O2 in the Kidney
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Design and development of opto-electrochemical biosensing devices for diagnosing chronic kidney disease

Divya1, Darshna1, Aditi Sammi1

  • 1Laboratory of Bio-Physio Sensors and Nanobioengineering School of Biochemical Engineering, Indian Institute of Technology (BHU) Varanasi, Varanasi, Uttar Pradesh, India.

Biotechnology and Bioengineering
|July 13, 2023
PubMed

Insights

Early detection of chronic kidney disease (CKD) is crucial. Biosensors offer a promising solution for precise, cost-effective, and onsite diagnosis of CKD using key biomarkers.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Clinical Diagnostics

Background:

  • Chronic kidney disease (CKD) is a growing global health concern, projected to be the 5th leading cause of mortality by 2050.
  • Early detection of renal disease is vital to prevent severe kidney impairment and reduce the overall disease burden.
  • Traditional diagnostic methods face challenges, highlighting the need for advanced detection solutions.

Purpose of the Study:

  • To review globally developed biosensors for chronic kidney disease (CKD) detection.
  • To focus on the design, patterns, and real-world applicability of these biosensors.
  • To compare optical and electrochemical biosensing systems and their performance with key clinical biomarkers.

Main Methods:

  • Comprehensive review of existing literature on biosensors for CKD detection.
  • Detailed discussion of optical and electrochemical biosensor classifications.
  • Analysis of biosensor performance based on clinical biomarkers like albumin and creatinine.

Main Results:

  • Biosensors offer simpler, cost-effective, and precise onsite detection methods for CKD.
  • Optical and electrochemical biosensors are key technologies for kidney disease diagnosis.
  • Tabulated comparison of various biosensors detailing analytical performance, response time, specificity, and biological fluid compatibility.

Conclusions:

  • Biosensors represent a significant advancement in the diagnosis and prevention of CKD.
  • The review provides a valuable resource for understanding current biosensor technologies for CKD.
  • Further development and application of biosensors can improve early detection rates and patient outcomes for CKD.

Keywords:
Kidney dysfunctionbiosensing deviceclinical biomarkerselectrochemicalnanobioengineeringoptical

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