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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Special Features of Adaptive Immunity01:20

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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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CLA+ memory T cells in atopic dermatitis

Lídia Sans-de San Nicolàs1, Tali Czarnowicki2, Mübeccel Akdis3

  • 1Immunologia Translacional, Departament de Biologia Cel·lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc Científic de Barcelona (PCB), Barcelona, Spain.

Allergy
|July 13, 2023
PubMed
Summary
This summary is machine-generated.

Cutaneous lymphocyte-associated antigen (CLA)+ T cells are key players in atopic dermatitis, influencing immune responses, symptoms like pruritus, and treatment efficacy. Understanding these cells offers insights into skin diseases.

Keywords:
CLA+ T cellsatopic dermatitisbiomarkerskin-homingtranslational

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Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Atopic dermatitis involves complex immune dysregulation.
  • Cutaneous lymphocyte-associated antigen (CLA)+ T cells are a subset of memory T cells homing to the skin.
  • These cells play roles in skin inflammation and immune responses.

Purpose of the Study:

  • To review the translational information on CLA+ T cell mechanisms in atopic dermatitis pathology.
  • To consolidate understanding of CLA+ T cells in relation to disease mechanisms, biomarkers, and therapies.

Main Methods:

  • Literature review of studies on CLA+ T cells in atopic dermatitis.
  • Analysis of the association between CLA+ T cells and disease-specific factors like Staphylococcus aureus, Th2 response, IL-13, IL-31, and pruritus.
  • Examination of CLA+ T cell involvement in targeted therapy mechanisms, including dupilumab.

Main Results:

  • CLA+ T cells are implicated in Staphylococcus aureus mechanisms and abnormal Th2 immune responses in atopic dermatitis.
  • Factors such as IL-13, IL-31, and pruritus are linked to CLA+ T cell activity.
  • Early effects of dupilumab treatment in patients are associated with CLA+ T cell mechanisms.

Conclusions:

  • CLA+ T cells are central to understanding atopic dermatitis pathogenesis.
  • Their function aligns with T cells in the skin-associated lymphoid tissue, explaining their role in various skin diseases.
  • Targeting CLA+ T cells may be a therapeutic strategy for atopic dermatitis and other T cell-mediated skin conditions.