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Sex Differences in the Association Between Serum Testosterone and Kidney Function in the General Population
Anna C van der Burgh1,2, Elif Aribas2, M Arfan Ikram2
1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Kidney International Reports
|July 13, 2023
Summary
Testosterone
Area of Science:
- Endocrinology and Nephrology
Background:
- Limited evidence exists on testosterone's role in kidney function decline, particularly in women.
- Population-based studies are needed to clarify these associations.
Purpose of the Study:
- To investigate the association between serum testosterone levels and kidney function in a large population-based cohort of men and women.
- To explore potential sex differences in this relationship.
Main Methods:
- Included 4095 men and 5389 women (≥45 years) with measurements of serum testosterone, SHBG, creatinine, and cystatin C.
- Assessed kidney function using estimated glomerular filtration rate (eGFRcreat, eGFRcys) and urine albumin-to-creatinine ratio (ACR).
- Employed linear regression and linear mixed models, stratified by sex.
Main Results:
- In men, higher free testosterone correlated with lower eGFRcreat and ACR, and higher eGFRcys.
- Higher total testosterone in men was linked to better eGFRcreat.
- In women, higher free testosterone was associated with lower eGFRcreat and eGFRcys over time.
Conclusions:
- Sex differences in testosterone's association with kidney function were observed: positive in men, negative in women.
- Serum cystatin C-based eGFR may be a more sensitive marker than creatinine-based eGFR for these associations.
- Further research is warranted to confirm these findings and explore underlying mechanisms.
Keywords:
albumin-to-creatinine ratioestimated glomerular filtration rategeneral populationlongitudinalsex differencestestosteroneMore Related Videos
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