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Reassessing Preterm Birth Prevention After the Withdrawal of 17-α Hydroxyprogesterone Caproate
1Denver Health Medical Center and the University of Colorado School of Medicine, Aurora, Colorado.
Limited options remain for preventing recurrent preterm birth. This review examines current evidence for vaginal progesterone, low-dose aspirin, and cerclage, exploring future prevention strategies.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Neonatal Health
Background:
- Recent FDA withdrawal of 17-α hydroxyprogesterone caproate impacts preterm birth prevention.
- Questionable efficacy of pessary for short cervix limits obstetric options.
- Healthcare providers face challenges in managing recurrent preterm birth.
Conclusions:
- Despite recent setbacks, several effective interventions for preterm birth prevention remain available.
- Optimizing the use of current therapies and exploring new approaches are crucial.
- Continued research is essential to reduce the incidence of preterm birth and improve neonatal outcomes.
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